Dr Albert Goldbeter

Professeur

Unité de Chronobiologie Théorique
Faculté des Sciences
Campus Plaine, C.P. 231
Université Libre de Bruxelles
1050 Brussels, Belgium

email: agoldbet

ulb.ac.be
Phone: (32-2) 6505772
Fax: (32-2) 6505767

Education

Licence en Chimie, Université Libre de Bruxelles, 1969

PhD, Université Libre de Bruxelles, 1973

Agrégation de l'Enseignement Supérieur, Université Libre de Bruxelles, 1988

Research Interests

Modeling the molecular regulatory mechanisms of biological rhythms: Circadian rhythms and related disorders of the sleep-wake cycle, segmentation clock, cell cycle, metabolic oscillations, oscillations and waves of cyclic AMP in Dictyostelium cells, oscillations and waves of calcium, pulsatile hormone secretion (GnRH, insulin), frequency encoding of pulsatile signals, oscillatory shuttling of transcription factors, complex oscillatory phenomena, transitions between periodic and chaotic behavior.

Threshold phenomena in enzyme regulation through phosphorylation-dephosphorylation ("zero-order ultrasensitivity").

Coexistence of multiple steady states (bistability).

List of publications

1) Books:

Goldbeter A (2018) Au coeur des rythmes du vivant. La vie oscillatoire, nouvelle édition revue et augmentée, 406 p., Odile Jacob, Paris, 2018: https://www.odilejacob.fr/catalogue/sciences/biologie/au-coeur-des-rythmes-du-vivant_9782738144065.php

Sur ce lien, en cliquant sur "feuilleter cet ouvrage" vous aurez accès aux premières page du livre, dont l'Introduction qui en détaille l'esprit et le contenu.

Goldbeter A (2010) La vie oscillatoire. Au coeur des rythmes du vivant. Odile Jacob, Paris, 367 p.

Table des matières

Articles de presse sur "La Vie oscillatoire":

La Libre Belgique, 10-11 novembre 2010
Le Soir, 4-5 décembre 2010
Le Journal du Médecin, 30 novembre 2010
EOS Sciences, mars-avril 2011
La Recherche, janvier 2011
Médecine/Sciences, mars 2011
Revue des Questions Scientifiques, 2011

Emissions radio

Podcast ULB, 18 janvier 2011

Goldbeter A (1996) Biochemical Oscillations and Cellular Rhythms: The molecular bases of periodic and chaotic behaviour. Cambridge University Press, Cambridge, 605 pp.

Goldbeter A (1990) Rythmes et chaos dans les systèmes biochimiques et cellulaires. Masson, Paris, 304 pp.

2) Articles

2022

Goldbeter A, Yan J (2022) Multi-synchronization and other patterns of multi-rhythmicity in oscillatory biological systems. Interface Focus 12:20210089 [PDF].

Pavlidis E, Campillo F, Goldbeter A, Desroches M (2022) Multiple-timescale dynamics, mixed mode oscillations and mixed affective states in a model of bipolar disorder. Cognitive Neurodynamics, in press [PDF].

2021

Goldbeter A, Leloup J-C (2021) From circadian clock mechanism to sleep disorders and jet lag: Insights from a computational approach. Biochemical Pharmacology, 191:114482 [Article].

2020

Goldbeter A (2020) "Coronavirus" In: "Systèmes humains par temps de confinement", Cahiers Critiques de Thérapie Familiale et de Pratiques de Réseaux 65, 13-15 [PDF].

Zhang R, Gonze D, Hou X, You X, Goldbeter A (2020) A computational model for the cold response pathway in plants, Front. Physiol., 11:591073. [Article].

2019

Farshadi E, Yan J, Leclere P, Goldbeter A, Chaves I and van der Horst GTJ (2019) The positive circadian regulators CLOCK and BMAL1 control G2/M cell cycle transition through Cyclin B1. Cell Cycle 18:1, 16-33, DOI: 10.1080/15384101.2018.1558638 ( https://doi.org/10.1080/15384101.2018.1558638)

Gérard C, Gonze D, Goldbeter A (2019) Revisiting a skeleton model for the mammalian cell cycle: from bistability to Cdk oscillations and cellular heterogeneity. J. Theor. Biol. 461, 276-290. (Available online 21 October 2018)

Yan J, Goldbeter A (2019) Multi-rhythmicity generated by coupling two cellular rhythms. J. R. Soc. Interface 16(152): 20180835. doi: 10.1098/rsif.2018.0835 [ pdf file]

Yan J, Goldbeter A (2019) Robust synchronization of the cell cycle and the circadian clock through bidirectional coupling. J. R. Soc. Interface 16: 20190376. [pdf file]

2018

Goldbeter A (2018) Dissipative structures in biological systems: bistability, oscillations, spatial patterns and waves. Phil. Trans. R. Soc. A 376 : 20170376. (http://dx.doi.org/10.1098/rsta.2017.0376)

Gonze D, Gérard C, Wacquier B, Woller A, Tosenberger A, Goldbeter A and Dupont G (2018) Modeling-based investigation of the effect of noise in cellular systems. Frontiers in Molecular Biosciences 5, 34.

2017

Goldbeter A (2017) Dissipative structures and biological rhythms. Chaos 27, 104612; doi: 10.1063/1.4990783 (View online: http://dx.doi.org/10.1063/1.4990783).

2016

De Mot L, Gonze D, Bessonnard S, Chazaud C, Goldbeter A and Dupont G (2016) Cell fate specification on tristability in the inner cell mass of mouse blastocysts. Biophys. J. 110, pp. 710-722. [pdf file]

Gérard C, Goldbeter A (2016) Dynamics of the mammalian cell cycle in physiological and pathological conditions. WIREs Syst. Biol. Med. 8: 140-56. doi: 10.1002/wsbm.1325. Epub 2015 Nov 27.

Goldbeter A (2016) Rythmes du vivant et rythme de vie : vers un décrochage? Cahiers critiques de thérapie familiale et de pratiques de réseaux 56: 233-252. DOI 10.3917/ctf.056.0233.

2015

Goldbeter A, Gérard C (2015) From simple to complex oscillatory behavior in cellular regulatory systems. In: Engineering Chemical Complexity II. World Scientific Lecture Notes in Complex Systems, Vol. 12, pp. 1-21 (A Mikhailov and G Ertl, Eds.). World Scientific, Singapore.

2014

Bessonnard S, De Mot L, Gonze D, Barriol M, Dennis C, Goldbeter A, Dupont G and Chazaud C (2014) Gata6, Nanog, and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network. Development. 141: 3637-48. doi: 10.1242/dev.109678. Epub 2014 Sep 10

Gérard C, Goldbeter A (2014) The balance between cell cycle arrest and cell proliferation: control by the extracellular matrix and by contact inhibition. Interface Focus 4: 20130075. (pdf available in open access at http://dx.doi.org/10.1098/rsfs.2013.0075)

2013

Goldbeter A (2013) Oscillatory enzyme reactions and Michaelis-Menten kinetics. FEBS Lett. 587, 2778-2784. doi:pii: S0014-5793(13)00560-7. 10.1016/j.febslet.2013.07.031. [Epub ahead of print]

Goldbeter A (2013) Origin of cyclicity in bipolar disorders: A computational approach. Pharmacopsychiatry 46 (Suppl. 1): S44-S52.

Leloup J-C, Goldbeter A (2013) Critical phase shifts slow down circadian clock recovery: Implications for jet lag. J. Theor. Biol. 333, 47-57.

2012

Gérard C, Goldbeter A (2012) From quiescence to proliferation : Cdk oscillations drive the mammalian cell cycle. Front. Physio. 3:413, doi: 10.3389/fphys.2012.00413. [pdf file]

Gérard C, Goldbeter A (2012) Entrainment of the mammalian cell cycle by the circadian clock : Modeling two coupled cellular rhythms. PLoS Comput. Biol. 8 (5): e1002516. http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002516.

Gérard C, Goldbeter A (2012) The cell cycle is a limit cycle. Math. Models Nat. Phenom. 7: 126-166.

Gérard C, Gonze D, Goldbeter A (2012) Effect of positive feedback loops on the robustness of oscillations in the network of cyclin-dependent kinases driving the mammalian cell cycle. FEBS Journal 279: 3411-3431. doi: 10.1111/j.1742-4658.2012.08585.x.

Goldbeter A (2012) La Vie oscillatoire: les bases chimiques des rythmes du vivant. Chimie nouvelle 109: 1-5.

Goldbeter A, Gérard C, Gonze D, Leloup J-C, Dupont G (2012) Systems biology of cellular rhythms. FEBS Lett. 586, 2955-2965. [pdf file]

2011

Altinok A, Gonze D, Lévi F, Goldbeter A (2011) An automaton model for the cell cycle. Royal Soc J Interface Focus 1, 36-47.

Gérard C, Goldbeter A (2011) A skeleton model for the network of cyclin-dependent kinases driving the mammalian cell cycle. R Soc J Interface Focus 1, 24-35.

Goldbeter A (2011) A model for the dynamics of bipolar disorders. Progr Biophys Mol Biol 105, 119-127.

Goldbeter A (2011) Rythmes du vivant: des horloges pour tous les temps (éditorial). Médecine/Sciences 27, 115-116.

Leloup J-C, Goldbeter A (2011) Modeling the dual role of PER phosphorylation and its effect on the period and phase of the mammalian circadian clock. IET Sys Biol 5(1): 44. [Abstract]

Lévi F., Altinok A, Goldbeter A (2011) Circadian rhythms and cancer chronotherapeutics. In: Cancer Systems Biology, Bioinformatics and Medicine: Research and Clinical Applications (Eds. F. Marcus and A. Cesario), Springer, Berlin, pp. 381-407.

2010

Gérard C, Goldbeter A (2010) From simple to complex patterns of oscillatory behavior in a model for the mammalian cell cycle containing multiple oscillatory circuits. Chaos 20, 045109. [pdf file]

Goldbeter A, Gérard C, Leloup J-C (2010) Biologie des systèmes et rythmes cellulaires. Médecine/Sciences 26, 49-56. [Abstract] [pdf file]

2009

Altinok A, Lévi F, Goldbeter A (2009) Identifying mechanisms of chronotolerance and chronoefficacy for the anticancer drugs 5-fluorouracil and oxaliplatin by computational modeling. Eur J Pharm Sci 36, 20-38. [Abstract] [pdf file]

Gérard C, Goldbeter A (2009) Temporal self-organization of the cyclin/Cdk network driving the mammalian cell cycle. Proc Natl Acad Sci USA 106, 21643-21648. [Abstract] [pdf file] [Supporting Information]

Gérard C, Gonze D, Goldbeter A (2009) Dependence of the period on the rate of protein degradation in minimal models for circadian oscillations. Phil Tran Royal Soc A 367, 4665-4683. [Abstract] [pdf file]

2008

Caldara M, Dupont G, Leroy F, Goldbeter A, De Vuyst L, Cunin R (2008) Arginine biosynthesis in Escherichia coli. Experimental perturbation and mathematical modeling. J Biol Chem 283, 6347-58. [Abstract] [pdf file]

Goldbeter A (2008) Biological rhythms: Clocks for all times. (Guest editorial) Curr Biol 18, R751-R753. [pdf file]

Goldbeter A, Pourquié O (2008) Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways. J Theor Biol 252, 574-585. [Abstract] [pdf file]

Gonze D, Jacquet M, Goldbeter A (2008) Stochastic modeling of nucleocytoplasmic oscillations of the transcription factor Msn2 in yeast. J R Soc Interface 5 Suppl 1, S95-109. [Abstract] [pdf file]

Gonze D, Markadieu N, Goldbeter A (2008) Selection of in-phase or out-of-phase synchronization in a model based on global coupling of cells undergoing metabolic oscillations. Chaos 18, 037127. [Abstract] [pdf file]

Leloup J-C and Goldbeter A (2008) Modeling the circadian clock : From molecular mechanism to physiological disorders. BioEssays 30, 590-600. [Abstract] [pdf file]

Lévi F, Altinok A, Clairambault J, Goldbeter A (2008) Implications of circadian clocks for the rhythmic delivery of cancer therapeutics. Philos Transact A Math Phys Eng Sci 366, 3575-3598. [Abstract] [pdf file]

Tyson JJ, Albert R, Goldbeter A, Ruoff P, Sible J (2008) Biological switches and clocks. J R Soc Interface 5 Suppl 1, S1-8. [Abstract] [pdf file]

2007

Altinok A, Lévi F, Goldbeter A (2007) A cell cycle automaton model for probing circadian patterns of anticancer drug delivery. Adv Drug Deliv Rev 59, 1036-53. (doi:10.1016/j.addr.2006.09.022). [Abstract] [pdf file]

Altinok A, Lévi F, Goldbeter A (2007) Optimizing temporal patterns of anticancer drug delivery by simulations of a cell cycle automaton. In: "Biosimulation in Drug Development", M. Bertau, E. Mosekilde and H.V. Westerhoff Eds., Wiley-VCH, pp. 275-297. [Abstract] [pdf file]

Garmendia-Torres C, Goldbeter A, Jacquet M (2007) Nucleocytoplasmic Oscillations of the Yeast Transcription Factor Msn2: Evidence for Periodic PKA Activation. Curr Biol 17, 1044-1049. [Abstract] [pdf file] [Supplemental data]

Goldbeter A (2007) Biological rhythms as temporal dissipative structures. Adv Chem Phys 135, 253-295. [pdf file]

Goldbeter A, Gonze D, Pourquié O (2007) Sharp developmental thresholds defined through bistability by antagonistic gradients of retinoic acid and FGF signaling. Dev Dyn 236, 1495-1508. [Abstract] [pdf file]

2006

Goldbeter A (2006) A model for the dynamics of human weight cycling J Biosci 31, 101-108. [Abstract] [pdf file]

Erneux T and Goldbeter A (2006) Rescue of the quasi-steady-state approximation in a model for oscillations in an enzymatic cascade. SIAM J. Appl. Math 67, 305-320. [Abstract] [pdf file]

Goldbeter A (2006) Oscillations and waves of cyclic AMP in Dictyostelium: A prototype for spatio-temporal organization and pulsatile intercellular communication. Bull Math Biol 68, 1095-1109. [Abstract] [pdf file]

Gonze D and Goldbeter A (2006) Circadian rhythms and molecular noise. Chaos 16(2), 26110. [Abstract] [pdf file]

Kurosawa G and Goldbeter A (2006) Amplitude of circadian oscillations entrained by 24-h light-dark cycles. J Theor Biol 242, 478-488. [Abstract] [pdf file]

Leloup J-C, Gonze D, and Goldbeter A (2006) Computational models for circadian rhythms : Deterministic versus stochastic approaches. In : "Computational Systems Biology", A Kriete and R Eils eds, pp. 249-291 (Elsevier Academic Press, Burlington-San Diego, USA). [Abstract] [pdf file]

2005

Goldbeter A (2005) Zero-order switches and developmental thresholds Mol Syst Biol doi:10.1038/msb4100042. [Article pdf]

2004

Goldbeter A (2004) Le sens du rythme. Vivant 4. [Article pdf]

Goldbeter A (2004) Computational biology: A propagating wave of interest . Curr Biol 14, R601-R602. [pdf file]

Gonze D, Halloy J, and Goldbeter A (2004) Stochastic models for circadian oscillations : Emergence of a biological rhythm. Int J Quantum Chem 98, 228-238. [Abstract] [pdf file]

Gonze D, Halloy J, and Goldbeter A (2004) Emergence of coherent oscillations in stochastic models for circadian rhythms. Physica A: Statistical Mechanics and its Applications 342, 221-233. [Abstract] [pdf file]

Igoshin OA, Goldbeter A, Kaiser D, and Oster G (2004) A biochemical oscillator explains several aspects of Myxococcus xanthus behavior during development. Proc Natl Acad Sci USA 101, 15760-5. [Abstract] [pdf file]

Leloup J-C and Goldbeter A (2004) Modeling the mammalian circadian clock: Sensitivity analysis and multiplicity of oscillatory mechanisms. J Theor Biol 230, 541-562. [Abstract] [pdf file]

2003

Dupont G, Houart G, and Goldbeter A (2003) From simple to complex Ca2+ oscillations: Regulatory mechanisms and theoretical models. In Lectures Notes in Physics. Understanding calcium dynamics. Experiments and theory. M. Falcke and D. Malchow (eds). Springer (Berlin), pp 131-152. [Abstract]

Forger DB, Dean II DA, Gurdziel K, Leloup J-C, Lee C, Von Gall C, Etchegaray J-P, Kronauer RE, Goldbeter A, Peskin CS, Jewett ME, and Weaver DR (2003) Development and validation of computational models for mammalian circadian oscillators. OMICS 7, 385-398. [Abstract] [pdf file]

Goldbeter A (2003) Biologie computationnelle des rythmes circadiens.Bull Cl Sci Acad R Belg XIV, 67-82.

Goldbeter A (2003) Ilya Prigogine (1917-2003). J Biosci 28, 657-559. [pdf file]

Goldbeter A and Leloup J-C (2003) La modélisation des rythmes du vivant. Pour la Science 314, 70-76. [Abstract] [pdf file]

Gonze D, Halloy J, and Goldbeter A (2003) Deterministic and stochastic models for circadian rhythms. Pathol Biol (Paris) 51, 227-230. [Abstract] [pdf file]

Gonze D, Halloy J, Leloup J-C, and Goldbeter A (2003) Stochastic models for circadian rhythms: Effect of molecular noise on periodic and chaotic behaviour. CR Biologies 326, 189-203. [Abstract] [pdf file]

Jacquet M, Renault G, Lallet S, de Mey J, and Goldbeter A (2003) Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisae. J Cell Biol 161, 497-505. [Abstract] [pdf file]

Jacquet M, Renault G, Lallet S, de Mey J, and Goldbeter A (2003) Oscillatory behavior of the nuclear localization of the transcription factors Msn2 and Msn4 in response to stress in yeast. TheScientificWorldJOURNAL 3, 609-612. [pdf file]

Leloup J-C and Goldbeter A (2003) Toward a detailed computational model for the mammalian circadian clock. Proc Natl Acad Sci USA 100, 7051-7056. [Abstract] [pdf file] [Supporting Information]

Pourquié O, and Goldbeter A (2003) Segmentation clock: Insights from computational models. Curr Biol 13, R632-R634. [Abstract] [pdf file]

2002

Goldbeter A (2002) Computational approaches to cellular rhythms. Nature 420, 238-45. [Abstract] [pdf file]

Goldbeter A and Claude D (2003) Time-patterned drug administration: Insights from a modeling approach. Chronobiol Int 19, 157-175. [Abstract]

Gonze D, Halloy J, and Goldbeter A (2002) Deterministic versus stochastic models for circadian rhythms. J Biol Phys, 28, 637-653. [Abstract] [pdf file]

Gonze D, Halloy J, and Goldbeter A (2002) Robustness of circadian rhythms with respect to molecular noise. Proc Natl Acad Sci USA 99, 673-678. [Abstract] [pdf file] [Supporting Information]

Gonze D, Roussel M, and Goldbeter A (2002) A Model for the enhancement of fitness in cyanobacteria based on resonance of a circadian oscillator with the external light-dark cycle. J Theor Biol 214, 577-597. [Abstract] [pdf file]

Halloy J, Bernard BA, Loussouarn G, and Goldbeter A (2002) The follicular automaton model: effect of stochasticity and of synchronization of hair cycles. J Theor Biol 214, 469-479. [Abstract] [pdf file]

2001

Goldbeter A, Gonze D, Houart G, Leloup J-C, Halloy J, and Dupont G (2001) From simple to complex oscillatory behavior in metabolic and genetic control network. Chaos 11, 247-260. [Abstract] [pdf file]

Goldbeter A (2001) Les rythmes et l'incertain. In : L'homme devant l'incertain (I. Prigogine, Ed.), Editions Odile Jacob, Paris, pp. 119-139.

Gonze D and Goldbeter A (2001) A model for a network of phosphorylation-dephosphorylation cycles displaying the dynamics of dominoes and clocks. J Theor Biol 210, 167-186. [Abstract] [pdf file & erratum]

Leloup J-C and Goldbeter A (2001) A molecular explanation for the long-term suppression of circadian rhythms by a single light pulse. Am J Physiol Regulatory Integrative Comp Physiol 280, R1206-R1212. [Abstract] [pdf file]

2000

Goldbeter A, Dupont G, and Halloy J (2000) The frequency encoding of pulsatility. Novartis Found Symp 227, 19-45. [Abstract]

Gonze D and Goldbeter A (2000) Entrainment versus chaos in a model for a circadian oscillator driven by light-dark cycles. J Stat Phys 101, 649-663.

Gonze D, Leloup J-C, and Goldbeter A (2000) Theoretical models for circadian rhythms in Neurospora and Drosophila. Comptes Rendus Hebd Acad Sci (Paris) Ser III 323, 57-67. [Abstract] [pdf file]

Guidi GM and Goldbeter A (2000) Oscillations and bistability predicted by a model for a cyclical bienzymatic system involving the regulated isocitrate dehydrogenase reaction. Biophys Chem 83, 153-170. [Abstract] [pdf file]

Halloy J, Bernard BA, Loussouarn G, and Goldbeter A (2000) Modeling the dynamics of human hair cycles by a follicular automaton. Proc Natl Acad Sci USA 97, 8328-8333. [Abstract] [pdf file]

Leloup J-C, and Goldbeter A (2000) Modeling the molecular regulatory mechanism of circadian rhytms in Drosophila. BioEssays 22, 84-93. [Abstract] [pdf file]

Roussel MR, Gonze D, and Goldbeter A (2000) Modeling the differential fitness of cyanobacterial strains whose circadian oscillators have different free-running periods: Comparing the mutual inhibition and substrate depletion hypotheses. J Theor Biol 205, 321-340. [Abstract] [pdf file]

1999

Houart G, Dupont G, and Goldbeter A (1999) Bursting, chaos and birhythmicity originating from self-modulation of the inositol 1,4,5-triphosphate signal in a model for intracellular Ca²⁺ oscillations. Bull Math Biol 61, 507-530. [Abstract] [pdf file]

Leloup J-C and Goldbeter A (1999) Chaos and birhythmicity in a model for circadian oscillations of the PER and TIM proteins in Drosophila. J Theor Biol 198, 445-459. [Abstract] [pdf file]

Leloup J-C, Gonze D, and Goldbeter A (1999) Limit cycle models for circadian rhythms based on transcriptional regulation in Neurospora and Drosophila. J Biol Rhythms 14, 433-448. [Abstract] [pdf file]

Romond P-C, Rustici M, Gonze D, and Goldbeter A (1999) Alternating oscillations and chaos in a model of two coupled biochemical oscillators driving successive phases of the cell cycle. Ann NY Acad Sci 879, 180-193. [Abstract] [pdf file]

1998

Dupont G, and Goldbeter A (1998) CaM kinase II as frequency decoder of Ca²⁺ oscillations. BioEssays 20, 607-610. [Abstract]

Goldbeter A (1998) Les bases moléculaires des rythmes biologiques. Chimie Nouvelle 16, 1871-1878.

Guidi G and Goldbeter A (1998) Bistability without hysteresis in chemical reaction systems: The case of nonconnected branches of coexisting steady states. J Phys Chem A 102, 7813-7820.

Guidi G and Goldbeter A (1998) From bistability to oscillations in the isocitrate dehydrogenase reaction. Biophys Chem 72, 201-210.

Guidi GM, Carlier MF, and Goldbeter A (1998) Bistability in the isocitrate dehydrogenase reaction: An experimentally based theoretical study. Biophys J 74, 1229-1240. [pdf file]

Halloy J, Lauzeral J, and Goldbeter A (1998) Modeling oscillations and waves of cAMP in Dictyostelium discoideum cells. Biophys Chem 72, 9-19. [Abstract] [pdf file]

Leloup J-C and Goldbeter A (1998) A model for circadian rhythms in Drosophila incorporating the formation of a complex between the PER and TIM proteins. J Biol Rhythms 13, 70-87. [Abstract] [pdf file]

Leloup J-C and Goldbeter A (1998) Modeling circadian rhythms of the PER and TIM proteins in Drosophila. In: Proceedings of the International Congress of Chronobiology. Biological Clocks: Mechanisms and Applications Y. Touitou (Ed.), Elsevier, Amsterdam, pp 81-88. [Abstract] [pdf file]

Perez-Iratxeta C, Halloy J, Moran F, Martiel JL, and Goldbeter A (1998) Coexistence of multiple propagating wave fronts in a regulated enzyme reaction model: Link with birhythmicity and multi-threshold excitability. Biophys Chem 74, 197-207. [pdf file]

1997

Borghans JAM, Dupont G, and Goldbeter A (1997) Complex intracellular calcium oscillations. A theoretical exploration of possible mechanisms. Biophys Chem 66, 25-41. [pdf file]

Dupont G and Goldbeter A (1997) Modeling oscillations and waves of cytosolic calcium. Nonlinear Analysis, Theory, Methods and Applications 30, 1781-1792. [pdf file]

Goldbeter A (1997) Modeling biochemical oscillations and cellular rhythms. Cur Sci 73, 933-939.

Guidi G and Goldbeter A (1997) Bistability without hysteresis in chemical reaction systems: A theoretical analysis of irreversible transitions between multiple steady states. J Phys Chem A 101, 9367-9376.

Lauzeral J, Halloy J, and Goldbeter A (1997) Desynchronization of cells on the developmental path triggers the formation of spiral waves of cAMP during Dictyostelium aggregation. Proc Natl Acad Sci USA 94, 9153-9158. [Abstract] [pdf file]

Leloup JC and Goldbeter A (1997) Temperature compensation of circadian rhythms: Control of the period in a model for circadian oscillations of the PER protein in Drosophila . Chronobiol Int 14, 511-520. [Abstract]

1996

Cardenas ML and Goldbeter A (1996) The glucose-induced switch between glycogen phosphorylase and glycogen synthase in the liver: Outlines of a theoretical approach. J Theor Biol 182, 421-426. [pdf file & erratum]

Dupont G, Pontès J, and Goldbeter A (1996) Modeling spiral Ca²⁺ waves in single cardiac cells: Role of the spatial heterogeneity created by the nucleus. Am J Physiol 271, C1390-C1399.

Goldbeter A (1996) From ultradian biochemical oscilations to circadian rhythms. In: Membranes and Circadian Rhythms. T. Vanden Driessche (Ed.), Springer, Berlin, pp. 67-93.

Goldbeter A and Guilmot JM (1996) Arresting the mitotic oscillator and the control of cell proliferation: Insights from a cascade model for cdc2 kinase activation. Experientia 52, 212-216.

Goldbeter A and Guilmot JM (1996) Thresholds and oscillations in enzymatic cascades. J Phys Chem 100, 19174-19181.

Goldbeter A, Guilmot JM, and Romond PC (1996) Contr™le de la prolifération cellulaire: Vers de nouvelles stratégies suggérées par une modélisation de l'oscillateur mitotique. Pathol Biol 44, 172-178.

Guidi GM, Halloy J, and Goldbeter A (1995) Chaos suppresion by periodic forcing: Insights from Dictyostelium cells, from a multiply regulated biochemical system, and from the Lorenz model. In: Proceedings of the conference Chaos and Complexity (blois, 1993). Tr‰n Thanh V‰n et al. (Eds), Editions Frontières, Paris, pp. 135-146.

1995

Goldbeter A (1995) A model for circadian oscillations in the Drosophila period protein (PER). Proc R Soc Lond B Biol Sci 261, 319-324. [pdf file]

1994

Dupont G and Goldbeter A (1994) Properties of intracellular Ca²⁺ waves generated by a model based on Ca ²⁺-induced Ca²⁺ release. Biophys J 67, 2191-2204.

Romond PC, Guilmot JM, and Goldbeter A (1994) The mitotic oscillator: Temporal self-organization in a phosphorylation-dephosphorylation enzymatic cascade. Berichte der Bunsen-Gesellschaft fŸr Physikalische Chemie 98, 1152-1159.

Segel LA and Goldbeter A (1994) Scaling in biochemical kinetics: Dissection of a relaxation oscillator. J Math Biol 32, 147-160.

1993

Dupont G and Goldbeter A (1993) One-pool model for Ca ²⁺ oscillations involving Ca²⁺ and inositol 1,4,5-triphosphate as co-agonists for Ca²⁺ release. Cell Calcium 14, 311-322. [pdf file]

Erneux T, Edstrom RD & Goldbeter A (1993) Enzyme sharing in phosphorylation-dephosphorylation cascades: The case whereone protein kinase (or phosphatase) acts on two different substrates. J Theor Biol 165, 43-61.

Goldbeter A (1993) Modeling the mitotic oscillator driving the cell division cycle. Comments on Theor Biol 3, 75-107.

Goldbeter A (1993) From periodic behavior to chaos in biochemical systems. In: Chaos in Chemical and Biochemical Systems (RJ Field and L Gyšrgyi, eds), World Scientific, Singapore, pp. 249-283.

Goldbeter A and Dupont G (1993) Wavelike propagation of cAMP and Ca²⁺ signals: Link with excitability and oscillations. In: Oscillations and Morphogenesis (L Rensing, ed.), M Dekker, New York, pp. 195-209.

Goldbeter A, Li YX, and Dupont G (1993) Pulsatile signalling in intercellular communication: An overview of theoretical and experimental aspects. In: Proceedings of the First European Conference on Mathematics Applied to Biology and Medicine (J Demongeot & V Capasso, eds.), Wuerz Publ., Winnipeg, Canada, pp. 429-439.

1992

Dupont G and Goldbeter A (1992) Oscillations and waves of cytosolic calcium: Insights from theoretical models. BioEssays 14, 485-493. Dupont G and Goldbeter A (1992) Protein phosphorylation driven by intracellular calcium oscillations: A kinetic analysis. Biophys Chem 42, 257-270.

Goldbeter A (1992) Comparison of electrical oscillations in neurons with induced or spontaneous cellular rhythms due to biochemical regulation In: Induced Rhythms of the Brain (E Basar & TH Bullock, eds.), Birkhauser, Boston, pp. 309-324.

Li YX and Goldbeter A (1992) Pulsatile signaling in intercellular communication. Periodic stimuli are more efficient than random or chaotic signals in a model based on receptor desensitization. Biophys J 61, 161-171. [pdf file]

Li YX, Halloy J, Martiel JL, and Goldbeter A (1992) Suppression of chaos and other dynamical transitions induced by intercellular coupling in a model for cAMP oscillations in Dictyostelium cells. Chaos 2, 501-512.

Li YX, Halloy J, Martiel JL, Wurster B, and Goldbeter A (1992) Suppression of chaos by periodic oscillations in a model for cyclic AMP signalling in Dictyostelium cells. Experientia 48, 603-606.

1991

Dupont G, Berridge MJ, and Goldbeter A (1991) Signal-induced Ca²⁺ oscillations: properties of a model based on Ca²⁺-induced Ca²⁺ release. Cell Calcium 12, 73-85.

Goldbeter A (1991) A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase. Proc Natl Acad Sci USA 88, 9107-9111. [pdf file]

Goldbeter A (1991) Du codage par fréquence des communications intercellulaires ˆ l'ébauche d'une chronopharamacologie généralisée. Bull Acad Roy Méd Belg 146, 113-127.

Goldbeter A and Dupont G (1991) Phosphorylation and the frequency encoding of signal-induced calcium oscillations. In: Cellular Regulation by Protein Phosphorylation (L Heilmeyer, ed.) Springer, Berlin, pp. 35-39.

Goldbeter A, Li YX, and Dupont G (1991) Periodicity and chaos in cAMP, hormonal and calcium signalling. In: Complex Dynamics and Biological Evolution (E Mosekilde, ed.), Plenum Press, New York, pp. 131-143.

1990

Dupont G, Berridge MJ, and Goldbeter A (1990) Latency correlates with period in a model for signal-induced Ca²⁺ oscillations based on Ca²⁺-induced Ca²⁺ release. Cell Regul 1, 853-861. [pdf file]

Goldbeter A, Li YX, and Dupont G (1990) Oscillatory dynamics in intercellular communication. Biomed Biochim Acta 49, 935-940.

Goldbeter A and Dupont G (1990) Allosteric regulation, cooperativity, and biochemical oscillations. Biophys Chem 37, 341-353.

Goldbeter A, Dupont G, and Berridge MJ (1990) Minimal model for signal-induced Ca²⁺ oscillations and for their frequency encoding through protein phosphorylation. Proc Natl Acad Sci USA 87, 1461-1465. [pdf file]

Goldbeter A and Koshland Jr DE (1990) Zero-order ultrasensitivity in interconvertible enzyme systems. In Control of Metabolic Processes (A Cornish-Bowden & ML Cardenas, eds.), Plenum, New York, pp. 173-182.

Goldbeter A and Wolpert L (1990) Covalent modification of proteins as a threshold mechanism in development. J Theor Biol 142, 243-250.

Halloy J, Li XY, martiel JL, Wurster B, and Goldbeter A (1990) Coupling chaotic and periodic cells results in a period-doubling route to chaos in a model for cAMP oscillations in Dictyostelium suspension. Phys Lett A 151, 33-36.

Li Y and Goldbeter A (1990) Frequency encoding of pulsatile signals of cAMP based on receptor desensitization in Dictyostelium cells. J Theor Biol 146, 355-367.

1989

Dupont G and Goldbeter A (1989) Theoretical insights into the origin of signal-induced calcium oscillations. In: Cell to Cell Signalling: From Experiments to Theoretical Models (A Goldbeter, ed.) Academic Press, London, pp. 461-474.

Goldbeter A and Li XY (1989) Frequency coding in intercellular communication. In: Cell to Cell Signalling: From Experiments to Theoretical Models (A. Goldbeter, ed.) Academic Press, London, pp. 415-432.

Goldbeter A and Wurster B (1989) Regular oscillations in suspensions of a putatively chaotic mutant of Dictyostelium discoideum. Experientia 45, 363-365.

Li Y and Goldbeter A (1989) Oscillatory isozymes as the simplest model for coupled biochemical oscillators. J Theor Biol 138, 149-174.

Li Y and Goldbeter A (1989) Frequency specificity in intercellular communication. Influence of patterns of periodic signaling on target cell responsiveness. Biophys J 55, 125-145. [pdf file]

1988

Goldbeter A (1988) Temps et rythmes biologiques. In: Redécouvrir le temps (A Nysenholc & JP Boon, eds.) Revue de l'Université de Bruxelles, pp. 93-102.

Goldbeter A (1988) Periodic signaling as an optimal mode of intercellular communication. News Physiol Sci 3, 103-105.

Goldbeter A, Decroly O, Li Y, Martiel JL, and Moran F (1988) Finding complex oscillatory phenomena in biochemical systems. An empirical approach. Biophys Chem 29, 211-217.

Goldbeter A and Martiel JL (1988) Developmental control of a biological rhythm: The onset of cAMP oscillations in Dictyostellium cells. In: From Chemical to Biological Organization (M Markus, S Muller & G Nicolis, eds.) Springer, Berlin, pp. 248-254.

Goldbeter A and Moran F (1988) Dynamics of a biochemical system with multiple oscillatory domains as a clue for multiple modes of neuronal oscillations. Eur Biophys J 15, 277-287. [pdf file]

1987

Decroly O and Goldbeter A (1987) From simple to complex oscillatory behaviour: Analysis of bursting in a multiply regulated biochemical system. J Theor Biol 124, 219-250. [pdf file]

Elkaïm M, Goldbeter A and Goldbeter-Merinfeld E (1987) Analysis of the dynamics of a family system in terms of bifurcations. J Social Biol. Struct. 10, 21-36 [pdf file]

Goldbeter A (1987) Adaptation, periodic signaling and receptor modification. In: Molecular Mechanisms of Desensitization (TM Konijn, PJM Van Haastert, H Van der Wel & MD Houslay, eds.) Springer, Berlin, pp. 43-62.

Goldbeter A (1987) Periodic signaling and receptor desensitization: from cAMP oscillations in Dictyostellium cells to pulsatile patterns of hormone secretion. In: Temporal Disorder in Human Oscillatory Systems (L Rensing, U an der Heiden & MC Mackey, eds.) Springer, Berlin, pp. 15-23.

Goldbeter A and Koshland Jr DE (1987) Energy expenditure in the control of biochemical systems by covalent modification. J Biol Chem 262, 4460-4471. [pdf file]

Goldbeter A and Martiel JL (1987) Periodic behaviour and chaos in the mechanism of intercellular communication governing aggregation of Dictyostellium amoeba. In: Chaos in Biological Systems (H Degn, AV Holden & LF Olsen, eds.) Plenum Press, New York, pp. 79-89.

Goldbeter A and Moran F (1987) Complex patterns of excitability and oscillations in a biochemical system. In: The Organization of Cell Metabolism (R Welch & J Clegg, eds.) Plenum Press, New York, pp. 291-306.

Martiel JL and Goldbeter A (1987) A model based on receptor desensitization for cyclic AMP signaling in Dictyostelium cells. Biophys J 52, 807-828. [pdf file]

Martiel JL and Goldbeter A (1987) Origin of bursting and birhythmicity in a model for cyclic AMP oscillations in Dictyostelium cells. Lect Notes Biomath 71, 244-255.

Moran F and Goldbeter A (1987) Periodic forcing of a biochemical system with multiple modes of oscillatory behaviour. In: Chaos in Biological Systems (H Degn, AV Holden & LF Olsen, eds.) Plenum Press, New York, pp. 67-77.

1986

Knox BE, Devreotes PN, Goldbeter A, and Segel LA (1986) A molecular mechanism for sensory adaptation based on ligand-induced receptor modification. Proc Natl Acad Sci USA 83, 2345-2349. [pdf file]

Segel LA, Goldbeter A, Devreotes PN, and Knox BE (1986) A mechanism for exact sensory adaptation based on receptor modification. J Theor Biol 120, 151-179.

1985

Decroly O and Goldbeter A (1985) Selection between multiple periodic regimes in a biochemical system: Complex dynamic behaviour resolved by use of one-dimensional maps. J Theor Biol 113, 649-671.

Goldbeter A (1985) Complex oscillatory phenomena, including multiple oscillations, in regulated biochemical systems. Biomed Biochim Acta 44, 881-889.

Goldbeter A (1985) Nonequilibrium sensitivity and threshold phenomena in biological systems. In: The Living State-II (RK Mishra, ed.) World Scientific Publ. Co., Singapour, pp. 47-66.

Goldbeter A & Martiel JL (1985) Birhythmicity in a model for the cyclic AMP signaling system of the slime mold Dictyostellium discoideum. FEBS Lett 191, 149-153. [pdf file]

Martiel JL and Goldbeter A (1985) Autonomous chaotic behaviour of the slime mould Dictyostelium discoideum predicted by a model for cyclic AMP signalling. Nature 313, 590-592.

Martiel JL and Goldbeter A (1985) Comportements périodiques, excitabilité et chaos dans un modèle pour la génération des signaux d'AMP cyclique chez l'amibe Dictyostelium discoideum. In: Actes du IVème Séminaire de l'Ecole de Biologie Théorique (G Benchetrit & J Demongeot, eds.) Editions du C.N.R.S., Paris, pp. 225-234.

Moran F and Goldbeter A (1985) Excitability with multiple thresholds. A new mode of dynamic behavior analyzed in a regulated biochemical system. Biophys Chem 23, 71-77.

Segel LA, Goldbeter A, Devreotes PN, and Knox BE (1985) A model for sensory response and exact adaptation mediated by receptor modification. In: Sensing and Response in Microorganisms (M Eisenbach & M Balaban, eds.) Elsevier, Amsterdam, pp. 175-183.

1984

Decroly O and Goldbeter A (1984) Coexistence entre trois régimes périodiques stables dans un système biochimique ˆ régulation multiple. C R Acad Sci (Paris) Ser II 298, 779-782.

Decroly O and Goldbeter A (1984) Multiple periodic regimes and final state sensitivity in a biochemical system. Phys Lett 105A, 259-262.

Decroly O and Goldbeter A (1984) Patterns of nonequilibrium sensitivity in biological systems. In: Fluctuations and Sensitivity in Nonequilibrium Systems (W Horsthemke & DK Kondepudi, eds.) Springer, Berlin, pp. 214-222.

Goldbeter A and Koshland Jr DE (1984) Ultrasensitivity in biochemical systems controlled by covalent modification. Interplay between zero-order and multistep effects. J Biol Chem 259, 14441-14447. [pdf file]

Goldbeter A, Martiel JL, and Decroly O (1984) From excitability and oscillations to birhythmicity and chaos in biochemical systems. In: Dynamics of Biochemical Systems (J Ricard & A Cornish-Bowden, eds.) Plenum Press, New York, pp. 173-212.

Martiel JL and Goldbeter A (1984) Oscillations et relais des signaux d'AMP cyclique chez Dictyostelium discoideum: Analyze d'un modèle fondé sur la désensibilisation du récepteur pour l'AMP cyclique. C R Acad Sci (Paris) Ser III 298, 549-552.

Moran F and Goldbeter A (1984) Onset of birhythmicity in a regulated biochemical system. Biophys Chem 20, 149-156.

1983

Goldbeter A and Decroly O (1983) Temporal self-organization in biochemical systems: periodic behavior vs chaos. Am J Physiol 245, R478-R483.

Goldbeter A and Martiel JL (1983) A critical discussion of plausible models for relay and oscillations of cyclic AMP in Dictyostellium discoideum. Lect Notes Biomath 49, 173-188.

1982

Decroly O and Goldbeter A (1982) Birhythmicity, chaos, and other patterns of temporal self-organization in a multiply regulated biochemical system. Proc Natl Acad Sci USA 79, 6917-6921. [pdf file]

Goldbeter A and Koshland Jr DE (1982) Sensitivity amplification in biochemical systems. Rev Biophys Q 15, 555-591. [pdf file]

Goldbeter A and Koshland Jr DE (1982) Simple molecular model for sensing and adaptation based on receptor modification with application to bacterial chemotaxis. J Mol Biol 161, 395-416.

Koshland Jr. DE, Goldbeter A, and Stock JB (1982) Amplification and adaptation in regulatory and sensory systems. Science 217, 220-225.

1981

Goldbeter A (1981) Bifurcations and the control of developmental transitions: Evolution of the cyclic AMP signalling system in Dictyostellium discoideum. In: Mathematical Biology. Towards a Molecular Science (T Burton, ed.) Pergamon Press, New York, pp. 79-95.

Goldbeter A and Koshland Jr DE (1981) An amplified sensitivity arising from covalent modification in biological systems. Proc Natl Acad Sci USA 78, 6840-6844. [pdf file]

Martiel JL and Goldbeter A (1981) Metabolic oscillations in biochemical systems controlled by covalent enzyme modification. Biochimie 63, 119-124.

Prigogine I and Goldbeter A (1981) Nonequilibrium self-organization in biochemical systems. In: Biochemistry of Exercise (J Poortmans, ed.) University Park Press, Baltimore, Md. Vol 3, pp. 3-12.

1980

Goldbeter A (1980) Models for oscillations and excitability in biochemical systems. In: Mathematical Models in Molecular and Cellular Biology (LA Segel, ed.) Cambridge Univ. Press, Cambridge, pp. 248-291.

Goldbeter A and Martiel JL (1980) Role of receptor desensitization in the mechanism of cAMP oscillations in Dictyostelium. Fed Proc 39, 1804. (Abstr.)

Goldbeter A and Segel LA (1980) Control of developmental transitions in the cyclic AMP signalling system of Dictyostelium discoideum. Differentiation 17, 127-135.

Goldbeter A and Venieratos D (1980) Analysis of the role of enzyme co-operativity in metabolic oscillations. J Mol Biol 138, 137-144.

1979

Venieratos D and Goldbeter A (1979) Allosteric oscillatory enzymes: Influence of the number of protomers on metabolic periodicities. Biochimie 61, 1247-1256.

1978

Goldbeter A (1978) Nonequilibrium behavior of biochemical systems. In: Alcohol and Aldehyde Metabolizing Systems (RG Thurman, JR Williamson, H Drott & B Chance, eds.) Academic Press, New York, Vol. 3, pp. 1-16.

Goldbeter A, Erneux T, and Segel LA (1978) Excitability in the adenylate cyclase reaction in Dictyostelium discoideum. FEBS Lett 89, 237-241. [pdf file]

Goldbeter A and Erneux T (1978) Oscillations entretenues et excitabilité dans la réaction de la phosphofructokinase. C R Acad Sci (Paris) Ser C 286, 63-66.

Hess B, Goldbeter A, and Lefever R (1978) Temporal, spatial and functional order in regulated biochemical and cellular systems. Adv Chem Phys 38, 363-413.

1977

Goldbeter A (1977) Thermodynamic and kinetic aspects of regulation. Acta Biochem Biophys Acad Sci Hung 12 141-148.

Goldbeter A (1977) On the role of enzyme cooperativity in metabolic oscillations. Analysis of the Hill coefficient in a model for glycolytic periodicities. Biophys Chemi 6, 95-99.

Goldbeter A and Segel LA (1977) Unified mechanism for relay and oscillations of cyclic AMP in Dictyostelium discoideum. Proc Natl Acad Sci USA 74, 1543-1547. [pdf file]

1976

Goldbeter A (1976) Kinetic cooperativity in the concerted model for allosteric enzymes. Biophys Chemist 4, 159-169.

Goldbeter A and Caplan SR (1976) Oscillatory enzymes. An Rev Biophys Bioengin 5, 449-476.

Goldbeter A and Nicolis G (1976) An allosteric enzyme model with positive feedback applied to glycolytic oscillations. In: Progress in Theoretical Biology (F Snell & R Rosen, eds.) Academic Press, New York, Vol. 4, pp. 65-160.

1975

Boiteux A, Goldbeter A, and Hess B (1975) Control of oscillating glycolysis of yeast by stochastic, periodic and steady source of substrate: A model and experimental study. Proc Natl Acad Sci USA 72, 3829-3838. [pdf file]

Goldbeter A (1975) Mechanism for oscillatory synthesis of cyclic AMP in Dictyostelium discoideum. Nature 253, 540-542.

Goldbeter A (1975) Contribution to the Faraday Symposium n¡9 Physical Chemistry of Oscillatory Phenomena, pp. 222-224.

1974

Goldbeter A (1974) Modulation of the adenylate energy charge by sustained metabolic oscillations. FEBS Lett 43, 327-330. [pdf file]

Goldbeter A (1974) Kinetic negative cooperativity in the allosteric model of Monod, Wyman and Changeux. J Mol Biol 90, 185-190.

1973

Goldbeter A (1973) Patterns of spatiotemporal organization in an allosteric enzyme model. Proc Natl Acad Sci USA 70, 3255-3259. [pdf file]

1972

Goldbeter A and Lefever R (1972) Dissipative structures for an allosteric model. Application to glycolytic oscillations. Biophys J 12, 1302-1315. [pdf file]

Goldbeter A and Lefever R (1972) Sustained oscillations in an allosteric enzyme model. In: Analysis and Simulation of Biochemical Systems (HC Hemker & B Hess, eds.) North-Holland, Amsterdam, pp. 163-169.

1971

Goldbeter A and Nicolis G (1971) Far from equilibrium synthesis of small polymer chains and chemical evolution. Biophysik 8, 212-226.

1969

Prigogine I, Lefever R, Goldbeter A, and Herschkowitz-Kaufman M (1969) Symmetry-breaking instabilities in biological systems. Nature 223, 913-916.

ULB - UTC: A. Goldbeter / Revised :